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Oxford University Hospitals NHS Foundation Trust

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Cytogenetics specimen requirements

General Specimen requirements

All samples MUST be accompanied by a referral form
Haemato-oncology sample referral card

Blood samples – Chromosomes/Karyotype

LITHIUM HEPARIN tube

  • Adults 2-5mls, Children 1-2mls, Fetal/Neonates 0.5-1ml
  • Blood samples should arrive within 24 hours of collection
  • Fetal/Neotatal samples should arrive the same day

Blood samples – Arrays

EDTA tube

  • Adults 2-5mls, Children 1-2mls, Fetal/Neonates 0.5-1ml
  • Blood samples should arrive within 24 hours of collection
  • Fetal/Neotatal samples should arrive the same day

Amniotic Fluid samples

Sterile UNIVERSAL

  • 10-20mls, room temperature
  • Should arrive within 24 hours - same day preferred

Chorionic Villis (CVS) samples

Transport Medium (supplied by the lab)

  • 10-20mgs, room temperature
  • Should arrive within 24 hours - same day preferred

Fetal Tissue samples/POC

Cord Blood – 0.5-1ml Paediatric LITHIUM HEPARIN
Placenta – 1 cubic cm, Transport medium
Skin Biopsy – full depth, Transport medium
Spleen/lung/other tissue – 1 cubic cm, Transport medium

  • Should arrive within 24 hours
  • Do NOT fix these tissues.

NIPT/NIPD samples

Blood should be sent in Streck tubes
Samples need to be kept at room temperature


Skin biopsy sample (adult/child)

Transport Medium (supplied by the lab)

  • Skin punch 2 cubic cm
  • Should arrive within 24 hours

Bone Marrow

Transport Medium (supplied by the lab), if not available, LITHIUM HEPARIN tube

  • 1ml of sample
  • Should arrive within 24 hours - same day preferred

Lymph Node

Transport Medium (supplied by the lab)

  • 1 cubic cm
  • Same day essential

Tumour

Transport Medium (supplied by the lab)

  • 1 cubic cm
  • Same day essential

Fixed tissue slides

  • Formalin fixed paraffin embedded (FFPE) tissue in blocks are stable at room temperature and require no special posting.
  • FFPE tissue sections mounted on slides need to be in a slide box and packaged with plenty of padding.

Additional samples types may be accepted for analysis. Clinicians are advised to contact the laboratory to discuss specific specimen requirements prior to arranging specimen collection

Last updated: 07-Nov-2018 by Claire Scott.

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