Adult solid tumours

Colorectal Carcinoma (M1)

• Colorectal Cancer targeted hotspot panel (KRAS, BRAF, NRAS, PIK3CA)
• MSI testing M1.4
• MLH1 promoter hypermethylation testing M1.5

Ovarian Carcinoma (M2)

Service under development

Endometrial Cancer

M215.2 MLH1 promoter hypermethylation

Non-Small Cell Lung Cancer (M4)

• Cytogenetic Tests
  • ROS1 rearrangement FISH (M4.6)
  • EML4-ALK FISH (M4.10); undertaken using an ALK breakapart probe only, therefore the partner gene is not identifiable
• Molecular Genetic Tests
  • EGFR hotspot tumour test (M4.4)
  • Lung Cancer targeted hotspot panel (EGFR, BRAF, KRAS)

Mucoepidermoid Carcinoma (M6)

MAML2 rearrangement FISH (M6.1)

Melanoma (M7)

• BRAF hotspot (M7.2)
• Melanoma targeted hotspot panel (BRAF, KIT, NRAS) (M7.1)

Uveal Melanoma (M187)

BRAF hotspot (M187.2)

Gastrointestinal Stromal Tumour (M8)

Targeted hotspot panel (KIT, PDGFRA) (M8.1)

Adenoid Cystic Carcinoma (M16)

MYB-NFIB or MYBL1-NFIB FISH (M16.1); undertaken using MYB, MYBL1 & NFIB breakapart probes

Secretory Carcinoma (Salivary Gland) (M17)

ETV6-NTRK3 FISH (M17.1); undertaken using ETV6 & NTRK3 breakapart probes

Renal Cell Carcinoma - Adult (M18)

• TFE3 rearrangement FISH (M18.1)
• Chromosome 3 FISH (M18.3)
• Chromosome 8 FISH (M18.4)
• Chromosome 7 & 17 FISH (M18.5)
• TFEB rearrangement FISH (M18.7)
  
• Additional chromosome copy number alterations can be investigated if considered clinically appropriate. These tests are not included in the TD and will be invoiced separately. Please contact us to discuss.