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Oxford University Hospitals NHS Foundation Trust

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Sarcoma

Alveolar Rhabdomyosarcoma (M42)

  • FOXO1 rearrangement FISH (M42.1)
  • PAX3-FOXO1 FISH (M42.2)
  • PAX7-FOXO1 FISH (M42.3

Alveolar Soft Part Sarcoma (M43)

TFE3 rearrangement FISH (M43.1)

Aneurysmal Bone Cyst (M44)

USP6 rearrangement FISH (M44.1)

It may be clinically relevant to undertake these studies when there is a differential diagnosis of another tumour type and the results will aid patient management.

Angiomatoid Fibrous Histiocytoma (M45)

  • EWSR1 rearrangement FISH (M45.1)
  • FUS rearrangement FISH (M45.2)

Clear Cell Sarcoma of Soft Tissue (M48)

EWSR1 rearrangement FISH (M48.1)

It may be clinically relevant to undertake these studies when there is a differential diagnosis of another tumour type and the results will aid patient management.

Dermatofibrosarcoma protuberans (M50)

COL1A1-PDGFB rearrangement FISH (M50.1)

Ewing Sarcoma of Bone (M56)

EWSR1 rearrangement FISH (M56.1)

Extraskeletal myxoid chondrosarcoma (M58)

NR4A3 rearrangement FISH (M58.1)

Inflammatory Myofibroblastic Tumour (M63)

TPM4-ALK FISH (m63.1); undertaken using an ALK breakapart probe only, therefore the partner gene is not identifiable.

Low Grade Fibromyxoid Sarcoma (M64)

FUS rearrangement FISH (M64.1)

It may be clinically relevant to undertake these studies when there is a differential diagnosis of another tumour type and the results will aid patient management.

Myoepithelial tumours of Soft Tissue (M66)

EWSR1 rearrangement FISH (M66.1)

Myxoid / Round Cell Liposarcoma (M67)

DDIT3 rearrangement FISH (M67.1)

It may be clinically relevant to undertake these studies when there is a differential diagnosis of another tumour type and the results will aid patient management.

Nodular Fasciitis (M69)

USP6 rearrangement FISH (M69.1)

It may be clinically relevant to undertake these studies when there is a differential diagnosis of another tumour type and the results will aid patient management.

Synovial sarcoma (M77)

SS18 rearrangement FISH (M77.1)

Well Differentiated / Dedifferentiated Liposarcoma (M79)

MDM2 copy number FISH (M79.1)

It may be clinically relevant to undertake these studies when there is a differential diagnosis of another tumour type and the results will aid patient management.