Colorectal Carcinoma (M1)
- Colorectal Cancer targeted hotspot panel (KRAS, BRAF, NRAS, PIK3CA)
- MSI testing M1.4
- MLH1 promoter hypermethylation testing M1.5
Ovarian Carcinoma (M2)
Service under development
Endometrial Cancer
M215.2 MLH1 promoter hypermethylation
Non-Small Cell Lung Cancer (M4)
- Cytogenetic Tests, available for urgent cases and those where a result is not available using RNAseq or other appropriate testing.
- ROS1 rearrangement FISH (M4.6)
- EML4-ALK FISH (M4.10); undertaken using an ALK breakapart probe only, therefore the partner gene is not identifiable
- Molecular Genetic Tests
- EGFR hotspot tumour test (M4.4)
- Lung Cancer targeted hotspot panel (EGFR, BRAF, KRAS)
Mucoepidermoid Carcinoma (M6)
MAML2 rearrangement FISH (M6.1), available for urgent cases and those where a result is not available using RNAseq or other appropriate testing.
Melanoma (M7)
- BRAF hotspot (M7.2)
- Melanoma targeted hotspot panel (BRAF, KIT, NRAS) (M7.1)
Uveal Melanoma (M187)
BRAF hotspot (M187.2)
Gastrointestinal Stromal Tumour (M8)
Targeted hotspot panel (KIT, PDGFRA) (M8.1)
Adenoid Cystic Carcinoma (M16)
MYB-NFIB or MYBL1-NFIB FISH (M16.1); undertaken using MYB, MYBL1 & NFIB breakapart probes, available for urgent cases and those where a result is not available using RNAseq or other appropriate testing.
Secretory Carcinoma (Salivary Gland) (M17)
ETV6-NTRK3 FISH (M17.1); undertaken using ETV6 & NTRK3 breakapart probes, available for urgent cases and those where a result is not available using RNAseq or other appropriate testing.
Renal Cell Carcinoma - Adult (M18)
- TFE3 rearrangement FISH (M18.1)
- Chromosome 3 FISH (M18.3)
- Chromosome 8 FISH (M18.4), available for urgent cases and those where a result is not available using RNAseq or other appropriate testing.
- Chromosome 7 & 17 FISH (M18.5)
- TFEB rearrangement FISH (M18.7)
