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Oxford University Hospitals NHS Foundation Trust

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Myeloproliferative neoplasm (M85)

Molecular investigations

Detection of the BCR-ABL fusion gene - screen for the presence of BCR-ABL fusion transcripts using multiplex PCR.

JAK2 V617F - targeted analysis by allele specific PCR and pyrosequencing. Appropriate samples are forwarded to the Wessex Genetics Laboratory for analysis of the MPN panel.

Myeloid panel (multi-target NGS panel (small variant)).

Karyotyping

As outlined in the Test Directory.

FISH

As outlined in the Test Directory other than tests M85.10, M85.28, M85.32 & M85.33 - if any of these tests are required please contact us to discuss forwarding the sample elsewhere.

Last reviewed:02 August 2021