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Oxford University Hospitals NHS Foundation Trust

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Oxford Adult Cystic Fibrosis Centre research

We are committed to raising the profile of cystic fibrosis in Oxford.

Dr Chapman is a Senior Lecturer at the University of Oxford with an active research programme into the genetics of susceptibility to infection. He has secured a total of more than £10 million in peer-reviewed grant funding.

Dr Flight has ongoing research interests in the fields of CF microbiology and lung disease.

Current research projects include:

  • Telehealth and Adherence with Therapy - led by Ali Gates, Lead Physiotherapist, OACFC
  • Pregnancy in Cystic Fibrosis - collaboration with Dr Lucy MacKillop, John Radcliffe Hospital
  • Antibiotic Resistance in the Microbiome Oxford (ARMORd Study) - collaboration with Nuffield Department of Medicine, University of Oxford
  • ACtiF Study - collaboration with Dr Martin Wildman and colleagues at the University of Sheffield.
    This study is looking at ways of improving adherence with medicines

If you are interested in finding out more about opportunities to get involved with research studies, please ask the team at your clinic visit.

For more information about Research at Oxford University Hospitals, please visit:


Peer-reviewed research publications

Flight WG, Smith A, Paisey C et al. Rapid detection of emerging pathogens and the loss of microbial diversity associated with severe lung disease in cystic fibrosis J Clin Microbiol Accepted manuscript posted online 15 April 2015, doi:10.1128/JCM.00432-15

Flight WG, Bright-Thomas RJ, Tilston P et al. Incidence and clinical impact of respiratory viruses in adults with cystic fibrosis. Thorax 2014; 69: 247-53

Flight WG, Bright-Thomas RJ, Sarran C et al. The effect of the weather on acute respiratory health events in adults with cystic fibrosis. Int J Biometeorol 2014;58:1845-51

Horsley A, Rousseau K, Ridley C, Flight W et al. Reassessment of the importance of mucins in determining sputum properties in cystic fibrosis. J Cyst Fibros 2014; 13: 260-6

IFITM3 and susceptibility to respiratory viral infections in the community. Journal of Infectious Diseases 2014; 209(7): 1028-31

Warnock L, Gates A, van der Schans CP. Chest physiotherapy compared to no chest physiotherapy for cystic fibrosis. Cochrane Database Syst Rev 2013;9:CD001401

Flight WG, Shaw J, Johnson S et al. Long-term non-invasive ventilation in adults with cystic fibrosis - experience over two decades. J Cyst Fibros 2012; 11: 187-92

McCann FJ, Chapman SJ, Yu WC et al. Ability of procalcitonin to discriminate infection from non-infective inflammation using two pleural disease settings. PLoS ONE 2012; 7(12): e49894

Jones AM, Flight W, Isalska B et al. Diagnosis of respiratory viral infections in cystic fibrosis by PCR using sputum samples. Eur Respir J 2011; 38: 1486-7

Khor CC*/Vannberg FO*/Chapman SJ*/Guo H* et al. CISH and susceptibility to infectious diseases. New England Journal of Medicine 2010; 362: 2092-101

Chapman SJ, Khor CC, Vannberg FO et al. Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study. Critical Care 2010; 14(6): R227

Chapman SJ, Khor CC, Vannberg FO et al. NFKBIZ polymorphisms and susceptibility to pneumococcal disease in European and African populations. Genes and Immunity 2010; 11(4): 319-25

Chapman SJ, Vannberg FO, Khor CC et al. Mannose binding lectin genotypes: lack of association with susceptibility to thoracic empyema. BMC Medical Genetics 2010; 11(1): 5

Wong SH, Gochhait S, Malhotra D, Pettersson FH, Teo YY, Khor CC, Rautanen A, Chapman SJ et al. Leprosy and the adaptation of human Toll-like receptor 1. PLoS Pathogens 2010; 6(7): e1000979