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Dermatology research Trials

The following research studies are being undertaken within Dermatology at the Churchill Hospital.


British Association of Dermatologists Biological Interventions Register

  • Consultant Dermatologist: Vanessa Venning and Tess Mcpherson
  • Lead Research Nurse: Melanie Westmoreland

British Association of Dermatologists Biological Interventions Register

The purpose of this research study is to assess whether the new biological treatments used in the treatment of psoriasis have any side effects when used long term in real life. These side effects, if any, will be compared to those seen with established treatments such as Ciclosporin , Methotrexate and PUVA (Light Treatment). The study therefore involves following up patients taking a number of different drugs for psoriasis and assessing any possible long-term side effects that may occur.

This study is being funded by the British Association of Dermatologists (BAD), a society of dermatologists aiming to give the best patient care to individuals with skin diseases.

There are currently over 150 hospital sites across the UK and Eire taking part in BADBIR by recruiting participants to join the Register. Once a patient has joined BADBIR, they are followed via their Dermatologist and Research Nurse until 2028 as we assess their clinical details. This is a data-collected study and patients will be asked to complete tick-box questionnaires at their Dermatology appointment. Dermatology participants will be provided with support and the Research Team contact details.

The website for the British Association of Dermatologists Biologic Interventions Register is

More information on BADBIR can be found in both the Participants and Clinicians sections of the website.

BADBIR is based at the University of Manchester and is part of the Arthritis Research UK Epidemiology Unit. Should you ever have any queries on any aspect of the Register please get in touch.

Tel: 0161 306 1896

SKIN Study

  • Chief Investigator: Professor Graham Ogg
  • Lead Research Nurse: Teena Mackenzie

The purpose of the SKIN Study is to understand the role of immune cells in contributing to inflammatory skin disease. Immune cells are usually involved in clearing infections, but there is evidence to suggest that they may also contribute to skin inflammation. If we can understand how this inflammation occurs then we may be able to design better treatments in the future. The research team will approach patients that have any inflammatory skin disease and also patients who do not have skin disease as they can be an important control group.

This study involves consenting to a blood sample and occasionally patients will be asked to consent for a skin biopsy.

This research study is led by Professor Ogg who has a team of graduate students and researchers working alongside. The research team have recently found a new type of immune cell in the skin which can contribute to skin inflammation. This exciting advance may open up new treatment possibilities in the future, as medicines may be developed to try to reduce the levels of the immune cells in the skin or stop their function.

The team is also learning about skin immune responses by studying reactions to bee and wasp stings, which can sometimes cause severe allergic reactions. They have found that there are similarities between the response to a sting and ways in which the skin heals after a wound. This finding will be important in conditions where the skin heals poorly or when there may be poor skin barrier, and may also shed light on new ways to treat inflammation.

The team has finished recruiting to an international clinical trial of a new tablet treatment for eczema which may affect how the immune cell functions, and will participate in another clinical trial of a new injection treatment for eczema.


  • Principal Investigator: Vanessa Venning
  • Lead Research Nurse: Melanie Westmoreland

This study is designed to test whether Secukinumab is effective, safe and well-tolerated in the treatment of moderate to severe chronic plaque-type psoriasis in patients who are inadequate responders to anti-TNFa therapy in a UK (and Republic of Ireland) specific population.

The SIGNATURE Study evaluates the efficacy of Secukinumab over an 18 month period.

This study is closed to new recruits though evaluation of patients on the trial continues.

SPOT Study

SPOT Questionnaire Study: Patient Preferences for Treatment of Actinic Keratoses (AK)

  • Principal Investigator: Rubeta Matin
  • Lead Research Nurse: Tracey Soanes

Several different AK treatments are available for patients and we wish to discover the overall preference for one type of treatment compared with another. There are short, sharp treatments and there are longer but gentler treatments. The intention is to publish the results of this research in a medical related journal and also on the Cancer Help website.

Cancer Help website:

Patients have been asked to complete a questionnaire whilst attending the Dermatology Department. We have recently closed this study as the research team have now fully recruited the number of patients required for this study.


Use of the Skin Cancer Quality of Life Impact Tool (SCQOLIT)

  • Chief Investigator: Rubeta Matin
  • Lead Research Nurse: Teena Mackenzie

Patient Reported Outcome Measures (PROMs) are questionnaires that participants fill in at various points during treatment to record how they feel. PROMs offer enormous potential to improve quality and results of Dermatology services providing validated evidence of health from a patient's perspective.

The purpose of this study is to investigate if a questionnaire assessing quality of life can be used in the Dermatology Skin Cancer Clinic for participants who are diagnosed with a skin cancer.

Patients once consented will be asked to complete a tick-box questionnaire, and then again three months later.


Metastases of cutaneous squamous cell carcinoma in organ transplant recipients

  • Chief Investigator: Rubeta Matin
  • Lead Research Nurse: Mel Westmoreland

This is an international observational study which Oxford is a participating centre. You will be invited to take part in this study if you have had an organ transplant and have a skin lesion which is suspected to be a squamous cell carcinoma (SCC). If you agree to participate you will be invited to have a photograph taken of your lesion, asked to answer a short questionnaire and then all information about your skin cancer will be entered into a database and followed up for two years. We do not require any more of your time.

These findings will then be shared with other centres in the UK and Europe (this will not include any personal details). It is hoped that by taking part in this research, you will be providing valuable information regarding the risk factors for metastases (spread of cancer) from SCC in organ transplant recipients.

IMAP Study

Investigating Medication Adherence in Psoriasis

  • Principal Investigator: Vanessa Venning
  • Lead Research Nurse: Tracey Soanes

This is a longitudinal study of adherence to medication in people living with psoriasis.

Research nurses will recruit patients who have newly consented to be included on the BADBIR Website. Once recruited patients will complete a series of 4 questionnaires over 2 years.

If you wish to find out any more details about any of these particular studies please contact the lead nurse for that study.


  • Chief Investigator: Professor Graham Ogg
  • Lead Research Nurse: Melanie Westmoreland

This study will evaluate the safety and efficacy of lebrikizumab administered subcutaneously in adult patients with moderate to severe atopic dermatitis who are inadequately controlled by topical corticosteroids. Recruitment to this study has recently closed and follow up is in progress.

HAIR Study

  • Chief Investigator: Dr Caroline Champagne
  • Lead Research Nurse: Teena Mackenzie

This study is investigating rare lichenoid, scarring and alopecic skin diseases. We are interested in a rare group of inflammatory skin diseases characterised by red, itchy, sore and often scarred or hairless skin.

This research study aims to find the relationship between gene mutations and the observable characteristics and traits of individuals affected. Patients will be asked about health and anonymised information will be collected. We aim to recruit 2000 patients. A blood sample will also be taken for DNA.

The results from this study will be published in high quality scientific journals and presented at national and international medical meetings.