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Tofacitinib in Treatment-Resistant Depression (TIDE)

Trial categories: Brain

Sponsoring organisation: University of Oxford

The effects of the anti-inflammatory drug, tofacitinib on emotional and reward processing in patients with treatment-resistant depression and elevated high-sensitivity C-reactive protein

Do you still feel low in mood despite antidepressant treatment?

Participants needed for a drug study investigating how a new anti-inflammatory affects emotional and rewarding information in depression.

We are looking for volunteers aged 18-65 who are currently feeling depressed despite antidepressant treatment to participate in a study investigating the effects of a new anti-inflammatory drug on emotional and reward processing.


Three appointments (one screening visit, two research visits) about 8 hours in total.

Who can participate?

People who feel depressed despite antidepressant treatment, aged 18 to 65.

What does the study involve?

Psychological tasks, one brain scan using functional Magnetic Resonance Imaging (fMRI), and taking medication for 7 days.

For more information in confidence, with no obligation to participate, please contact our research team at:

or visit

You will be reimbursed for your time!