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Effects of a new medication on emotional processing in people with treatment-resistant depression

Trial categories: Brain

Sponsoring organisation: University of Oxford

Do you feel low in mood despite antidepressant treatment?

We are looking for participants for an emotional decision-making drug study, the RESTART Study.

We are looking for people who are currently taking antidepressants but have been feeling sad, low or unmotivated more days than not despite this, to take part in a study.

You do not need to feel low all of the time, and may have felt this way only recently, throughout your treatment, or on and off (more details on our website

This study is exploring how a new medication affects emotional decision-making and involves psychological tasks and taking medication for 7 days.


Three appointments (one screening visit, one first dose appointment, and one research visit) about 11 hours in total.

Who can participate?

Participants who are currently taking an antidepressant but are still feeling depressed/low despite this, aged 18 to 65.

What does the study involve?

The study mainly involves taking medication for 7 days, computer-based psychological tasks and questionnaires

You will be reimbursed for your time and expenses.

For further information in confidence with no obligation to participate, contact us: