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Oxford University Hospitals NHS Foundation Trust

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Trial categories: Bones and joints; Women's health

Sponsoring organisation: University of Oxford

Hand Osteoarthritis: investigating Pain Effects in a randomised placebo-controlled feasibility study of Estrogen containing therapy (HOPE-e)

We are inviting women with painful hand osteoarthritis, aged 40-65, and between 1 and 10 years after menopause, to take part in this study.

Purpose of the study

We want to test whether taking a tablet of an estrogen-containing therapy once daily for 6 months improves hand pain in women with hand OA, when compared with taking a placebo tablet (inactive medication).

This study aims to find out whether it is acceptable to women with painful hand OA to take this type of treatment, and also what the best way of collecting some of the information is, to help us plan a full size trial. The study may also give us some idea of whether this treatment might work or not.

If you are interested in taking part in this study or would like more information, please contact the study team:


Telephone: +44 (0)1865 612661