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Oxford University Hospitals NHS Foundation Trust

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Does stimulating friendly gut bacteria improve brain function and behaviour?

Trial categories: Brain; Other

Sponsoring organisation: Wellcome Centre for Integrative Neuroimaging

Feeling sad or anxious?

Participants wanted for a brain study

"Does stimulating friendly gut bacteria improve brain function and behaviour?"

Study 1B

Researchers at the Nuffield Department of Clinical Neurosciences, University of Oxford are seeking healthy male or female volunteers aged 18 - 50 who may be feeling low in mood, sad or anxious, for a study testing the effect of a nutritional supplement on brain function.

The study aims to test if a naturally-occurring form of dietary fibre, taken daily over several weeks, can improve brain function and behaviour. Participants will be asked to consume the fibre supplement (or a placebo) daily with breakfast over 6 weeks.

Before and after the dietary intervention, participants will be asked to complete questionnaires (measuring mood, anxiety, stress, and attention), and to perform computerized behavioural tasks. They will also have the option to provide saliva samples and/or blood samples (to measure certain factors like hormone levels) if they wish.

To determine safety to participate, volunteers will first be interviewed and asked to complete questionnaires about their medical history.

This study involves six visits to the Oxford Centre for Functional MRI of the Brain on the John Radcliffe Hospital or the Department of Psychiatry at the University of Oxford. Each session will take no more than 3 hours. Volunteers will be compensated for their time.

If you are interested in participating and/or would like further information, please contact:

Dr Gershon Spitz: gershon.spitz@ndcn.ox.ac.uk

Thank you for your time.

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