Phospholipase A2 Receptor

PLA2R Antibody testing is peformed by a referral laboratory. This assay is only available to members of Oxford University Hospitals NHS Foundation Trust.

The Phosphlipase A2 receptor (PLA2R) was recently discovered as a target autoantigen in patients with idiopathic membranous nephropathy (IMN). Autoantibodies directed to PLA2R were found in 52-82% of individuals with IMN but only to a small percentage (5-25%) in sera from patients with secondary MN. Since anti-PLA2R are strongly associated with disease activity, it is thought they are pathogenic, but no clear mechanisms of pathogenesis for IMN have so far been identified.

This assay is performed at a referral laboratory (external users requiring serum PLA2R antibody levels are advised to contact the referral laboratory directly):

Department of Immunology
PO Box 894
SHEFFIELD
S5 7YT

Specimen requirements

Serum 1ml

Cost

Price on application

Laboratory turnaround time

28 days

Laboratory method

ELISA.

Calibration: Traceable to a manufacturers in-house master lot.
EQA scheme: Sample exchange scheme implemented.
IQC: In-house preparation and kit control.

Reference range/units

<14 RU/mL = Negative.
14 - 20 RU/mL = Borderline.
>20 RU/mL = Positive.

Associated tests

Not applicable

Shipping and storage

UK and Ireland

Ambient temperature and first class post. Hays DX users please enquire via email below.

International

Ambient temperature if courier will deliver within 72 hours otherwise consider refrigerated transport. Freezing is not a requirement.

Ensure delivery Monday to Friday 09:00 - 17:30.

Further information and contact details

For further information, email immunology.office@nhs.net