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Immunology Laboratory

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Publications

2017

Lennox BR, Palmer-Cooper EC, Pollak T, Hainsworth J, Marks J, Jacobson L, Lang B, Fox H, Ferry B, Scoriels L et al: Prevalence and clinical characteristics of serum neuronal cell surface antibodies in first-episode psychosis: a case-control study. Lancet Psychiatry 2017, 4(1):42-48.

2016

Kienzler AK, van Schouwenburg PA, Taylor J, Marwah I, Sharma RU, Noakes C, Thomson K, Sadler R, Segal S, Ferry B et al: Hypomorphic function and somatic reversion of DOCK8 cause combined immunodeficiency without hyper-IgE. Clin Immunol 2016, 163:17-21.

Dhalla F, Fox H, Davenport EE, Sadler R, Anzilotti C, van Schouwenburg PA, Ferry B, Chapel H, Knight JC, Patel SY: Chronic mucocutaneous candidiasis: characterization of a family with STAT-1 gain-of-function and development of an ex-vivo assay for Th17 deficiency of diagnostic utility. Clin Exp Immunol 2016, 184(2):216-227.

Culver EL, Sadler R, Simpson D, Cargill T, Makuch M, Bateman AC, Ellis AJ, Collier J, Chapman RW, Klenerman P et al: Elevated Serum IgG4 Levels in Diagnosis, Treatment Response, Organ Involvement, and Relapse in a Prospective IgG4-Related Disease UK Cohort. Am J Gastroenterol 2016, 111(5):733-743.

Ayers L, Turnbull C, Petousi N, Ferry B, Kohler M, Stradling J: Withdrawal of Continuous Positive Airway Pressure Therapy for 2 Weeks in Obstructive Sleep Apnoea Patients Results in Increased Circulating Platelet and Leucocyte-Derived Microvesicles. Respiration 2016, 91(5):412-413.

Nicholson T, Woods A, David J, Hoyles R (2016) Anti-synthetase syndrome: Validity of ANA as a screening tool - The Oxford interstitial lung disease service experience. Pulm Crit Care Med 1: DOI: 10.15761/PCCM.1000116.

2015

Stradling JR, Craig SE, Kohler M, Nicoll D, Ayers L, Nunn AJ, Bratton DJ: Markers of inflammation: data from the MOSAIC randomised trial of CPAP for minimally symptomatic OSA. Thorax 2015, 70(2):181-182.

Shah AS, Griffiths M, Lee KK, McAllister DA, Hunter AL, Ferry AV, Cruikshank A, Reid A, Stoddart M, Strachan F et al: High sensitivity cardiac troponin and the under-diagnosis of myocardial infarction in women: prospective cohort study. BMJ 2015, 350:g7873.

Miller A, Nightingale AL, Sammon CJ, Mahtani KR, Holt TA, McHugh NJ, Luqmani RA: Estimating the diagnostic accuracy of rheumatoid factor in UK primary care: a study using the Clinical Practice Research Datalink. Rheumatology (Oxford) 2015, 54(10):1882-1889.

Dhalla F, Murray S, Sadler R, Chaigne-Delalande B, Sadaoka T, Soilleux E, Uzel G, Miller J, Collins GP, Hatton CS et al: Identification of a novel mutation in MAGT1 and progressive multifocal leucoencephalopathy in a 58-year-old man with XMEN disease. J Clin Immunol 2015, 35(2):112-118.

Culver EL, Vermeulen E, Makuch M, van Leeuwen A, Sadler R, Cargill T, Klenerman P, Aalberse RC, van Ham SM, Barnes E et al: Increased IgG4 responses to multiple food and animal antigens indicate a polyclonal expansion and differentiation of pre-existing B cells in IgG4-related disease. Ann Rheum Dis 2015, 74(5):944-947.

Ayers L, Nieuwland R, Kohler M, Kraenkel N, Ferry B, Leeson P: Dynamic microvesicle release and clearance within the cardiovascular system: triggers and mechanisms. Clin Sci (Lond) 2015, 129(11):915-931.

2014

Sadler R, Bateman EA, Heath V, Patel SY, Schwingshackl PP, Cullinane AC, Ayers L, Ferry BL: Establishment of a healthy human range for the whole blood "OX40" assay for the detection of antigen-specific CD4+ T cells by flow cytometry. Cytometry B Clin Cytom 2014, 86(5):350-361.

Ayers L, Stoewhas AC, Ferry B, Latshang TD, Lo Cascio CM, Sadler R, Stadelmann K, Tesler N, Huber R, Achermann P et al: Circulating levels of cell-derived microparticles are reduced by mild hypobaric hypoxia: data from a randomised controlled trial. Eur J Appl Physiol 2014, 114(5):1067-1073.

Ayers L, Harrison P, Kohler M, Ferry B: Procoagulant and platelet-derived microvesicle absolute counts determined by flow cytometry correlates with a measurement of their functional capacity. J Extracell Vesicles 2014, 3.

Augustine D, Ayers LV, Lima E, Newton L, Lewandowski AJ, Davis EF, Ferry B, Leeson P: Dynamic release and clearance of circulating microparticles during cardiac stress. Circ Res 2014, 114(1):109-113.

2013

Stowhas AC, Latshang TD, Lo Cascio CM, Lautwein S, Stadelmann K, Tesler N, Ayers L, Berneis K, Gerber PA, Huber R et al: Effects of acute exposure to moderate altitude on vascular function, metabolism and systemic inflammation. PLoS One 2013, 8(8):e70081.

Roberts CA, Ayers L, Bateman EA, Sadler R, Magerus-Chatinet A, Rieux-Laucat F, Misbah SA, Ferry BL: Investigation of common variable immunodeficiency patients and healthy individuals using autoimmune lymphoproliferative syndrome biomarkers. Hum Immunol 2013, 74(12):1531-1535.

Ayers L, Stoewhas AC, Ferry B, Stradling J, Kohler M: Elevated levels of endothelial cell-derived microparticles following short-term withdrawal of continuous positive airway pressure in patients with obstructive sleep apnea: data from a randomized controlled trial. Respiration 2013, 85(6):478-485.

2012

Suchanek O, Sadler R, Bateman EA, Patel SY, Ferry BL: Immunophenotyping of putative human B1 B cells in healthy controls and common variable immunodeficiency (CVID) patients. Clin Exp Immunol 2012, 170(3):333-341.

Deshpande V, Zen Y, Chan JK, Yi EE, Sato Y, Yoshino T, Kloppel G, Heathcote JG, Khosroshahi A, Ferry JA et al: Consensus statement on the pathology of IgG4-related disease. Mod Pathol 2012, 25(9):1181-1192.

Cliffe ST, Bloch DB, Suryani S, Kamsteeg EJ, Avery DT, Palendira U, Church JA, Wainstein BK, Trizzino A, Lefranc G et al: Clinical, molecular, and cellular immunologic findings in patients with SP110-associated veno-occlusive disease with immunodeficiency syndrome. J Allergy Clin Immunol 2012, 130(3):735-742 e736.

Bateman EA, Ayers L, Sadler R, Lucas M, Roberts C, Woods A, Packwood K, Burden J, Harrison D, Kaenzig N et al: T cell phenotypes in patients with common variable immunodeficiency disorders: associations with clinical phenotypes in comparison with other groups with recurrent infections. Clin Exp Immunol 2012, 170(2):202-211.

2011

Sadler R, Chapman RW, Simpson D, Soonawalla ZF, Waldegrave EL, Burden JM, Misbah SA, Ferry BL: The diagnostic significance of serum IgG4 levels in patients with autoimmune pancreatitis: a UK study. Eur J Gastroenterol Hepatol 2011, 23(2):139-145.

Orange JS, Glessner JT, Resnick E, Sullivan KE, Lucas M, Ferry B, Kim CE, Hou C, Wang F, Chiavacci R et al: Genome-wide association identifies diverse causes of common variable immunodeficiency. J Allergy Clin Immunol 2011, 127(6):1360-1367 e1366.

Kohler M, Stoewhas AC, Ayers L, Senn O, Bloch KE, Russi EW, Stradling JR. The effects of CPAP therapy withdrawal in patients with obstructive sleep apnea: a randomised controlled trial. Am J Respir Crit Care Med. 2011 Nov; 184(10):1192-9

Medd P, Littlewood S, Danby R, Malladi R, Clifford R, Wareham D, Jeffery K, Ferry B, Roberts D, Peniket A et al: Paraproteinaemia after allo-SCT, association with alemtuzumab-based conditioning and CMV reactivation. Bone Marrow Transplant 2011, 46(7):993-999.

Ayers L, Kohler M, Harrison P, Sargent I, Dragovic R, Schaap M, Nieuwland R, Brooks SA, Ferry B: Measurement of circulating cell-derived microparticles by flow cytometry: sources of variability within the assay. Thromb Res 2011, 127(4):370-377.

Oxford work performed in Clinical laboratory Immunology

Rigaud S, Lopez-Granados E, Fugger L, Stephan JL, Fischer A, Picard C, Durandy A, Chapel H, Latour S.. Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Blood. 2011 Jul 14;118(2):252-61

2008-2010

Packwood K, Drewe E, Staples E, …, Ferry BL, Chapel HM. NOD2 polymorphisms in clinical phenotypes of common variable immunodeficiency disorders. Clin Exp Immunol. 2010 Sep;161(3):536-41.

Arnold DF, Timms A, Luqmani R, Misbah SA. Does a gating policy for ANCA overlook patients with ANCA associated vasculitis? An audit of 263 patients. J Clin Pathol. 2010 Aug;63(8):678-80.

Miller A, Chan M, Wiik A, Misbah SA, Luqmani RA. An approach to the diagnosis and management of systemic vasculitis. Clin Exp Immunol. 2010 May;160(2):143-60.

Arnold DF, Roberts AG, Thomas A, Ferry B, Morgan BP, Chapel H. A novel mutation in a patient with a deficiency of the eighth component of complement associated with recurrent meningococcal meningitis. J Clin Immunol. 2009 Sep;29(5):691-5

Davies HE, Sadler RS, Bielsa S, Maskell NA, Rahman NM, Davies RJ, Ferry BL, Lee YC. Clinical impact and reliability of pleural fluid mesothelin in undiagnosed pleural effusions. Am J Respir Crit Care Med. 2009 Sep 1;180(5):

Ayers L, Ferry B, Craig S, Nicoll D, Stradling JR, Kohler M. Circulating cell-derived microparticles in patients with minimally symptomatic obstructive sleep apnoea. Eur Respir J. 2009 Mar;33(3): 574-80.

Kohler M, Ayers L, Pepperell JC, Packwood KL, Ferry B, Crosthwaite N, Craig S, Siccoli MM, Davies RJ, Stradling JR. Effects of continuous positive airway pressure on systemic inflammation in patients with moderate to severe obstructive sleep apnoea: a randomised controlled trial.Thorax. 2009 Jan;64(1):67-73.

Wehr C, Kivioja T, Schmitt C, Ferry B, et al….. Warnatz K. The EUROclass trial: defining subgroups in common variable immunodeficiency. Blood. 2008 Jan 1;111(1):77-85.

Oxford work performed in Clinical laboratory Immunology

Picard C, von Bernuth H, Ghandil P, Chrabieh M, Levy O, ..., Chapel H Abel L, Puel A, Casanova JL. Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency. Medicine (Baltimore). 2010 Nov;89(6):403-25.

Salzer U, Bacchelli C, Chapel H, ...Grimbacher B. Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes. Blood. 2009 Feb 26;113(9):1967-76.

2005-2008

Curry NS, Misbah SA, Giangrande PL, Keeling DM. Achievement of immune tolerance in a patient with haemophilia B and inhibitory antibodies, complicated by an anaphylactoid reaction. Haemophilia. 2007 May;13(3):328-30.

Salt P, Banner C, Oh S, Yu LM, Lewis S, Pan D, Griffiths D, Ferry B, Pollard A. Social mixing with other children during infancy enhances antibody response to a pneumococcal conjugate vaccine in early childhood. Clin Vaccine Immunol. 2007

Tchilian EZ, Gil J, Navarro ML, Fernandez-Cruz E, Chapel H, Misbah S, Ferry B, Renz H, Schwinzer R, Beverley PC. Unusual case presentations associated with the CD45 C77G polymorphism. Clin Exp Immunol. 2006 Dec;146(3):448-54.

Ferry BL, Jones J, Bateman EA, Woodham N, Warnatz K, Schlesier M, Misbah SA, Peter HH, Chapel HM. Measurement of peripheral B cell subpopulations in common variable immunodeficiency (CVID) using a whole blood method. Clin Exp Immunol. 2005 Jun;140(3):532-9.

Oxford work performed in Clinical laboratory Immunology

Salzer U, Chapel HM, Webster AD, Pan-Hammarström Q, Schmitt-Graeff A, Schlesier M, Peter HH, Rockstroh JK, Schneider P, Schäffer AA, Hammarström L, Grimbacher B. Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Nat Genet. 2005 Aug;37(8):820-8.