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Cardiothoracic Services

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NHS Cardiac Research Team studies

Heart Failure

LV Only MPP With SyncAV

In the quest to evaluate the clinical benefits of Cardiac Resynchronisation Therapy (CRT) for heart failure patients, this study is designed to evaluate LV only pacing, single- and Multi-Point Pacing (MPP) combined with automatic adjusting of AV timing (SyncAV therapy) to improve electrical synchrony in heart failure patients with Left Bundle Branch Block (LBBB) and prolonged QRS duration.

LV Only MPP With SyncAV- ClinicalTrials.gov

MoreCRT MPP, WICS-LV, SOLVE CRT

These three studies are designed to evaluate efficiency of specialised pacemakers in improving the pumping action of the heart with an objective to relieve symptoms of fatigue and shortness of breath.

MoreCRT MPP, WICS-LV, SOLVE CRT - ClinicalTrials.gov

CardioMEMS-HF

This study is designed to evaluate a CardioMEMS-HF - CE marked sensing system that wirelessly monitors the pulmonary artery pressure and heart rate in heart failure patients who have been hospitalised for heart failure in the previous year.

CardioMEMS-HF - Abbott Cardiovascular

CardioMEMS-HF - ClinicalTrials.gov

IRONMAN

This study is designed to evaluate the long-term effectiveness and safety of intravenous iron infusions for patients with heart failure with an objective to improve symptoms and quality of life.

IRONMAN - ClinicalTrials.gov

Iron could reduce hospitalisation and help ease symptoms for people with failing hearts - University of Glasgow 2016

Abnormal Heart Rhythm

CRAFT

The objective of the study is to assess the use of a novel cryoballoon pulmonary vein isolation treatment to treat abnormal heart rhythms (astudy fibrillation, astudy flutter, or astudy tachycardia) compared to the standard radiofrequency (RF) ablation.

CRAFT - ClinicalTrials.gov

ASAP-TOO

For patients with astudy fibrillation who cannot take anticoagulants; a mesh umbrella is placed in the top chamber of the heart to prevent blood from pooling and clotting, thereby reducing the risk of stroke.

ASAP-TOO - Boston Scientific

NOAH-AFNET 6

To establish evidence-based guidelines for the use of anti-coagulant medicines to prevent stroke in patients who have episodes of very fast heart rhythms.

NOAH-AFNET 6 - Atrial Fibrillation Network

Biomarker-AF

The aim of this study is to understand the role of inflammation in electrical remodelling in Astudy Fibrillation through identification of novel biomarkers in patients undergoing ablation and cardioversion.

MINERVA

This study is designed to develop a screening test to identify people at risk of cardiac arrest or Sudden Cardiac Death Syndrome so they can be offered a defibrillator implant. This is an academic project funded by Heart Research UK and sponsored by the University of Leicester.

Praetorian

This is a randomised controlled study to evaluate the advantages and disadvantages of the sub-cutaneous implantable cardioverter defibrillator (SC-ICD) versus transvenous ICD (TV-ICD) to treat patients with ventricular arrhythmia. The main difference between these defibrillators is that TV-ICD requires wires into the heart whereas SC-ICD does not.

Praetorian - ClinicalTrials.gov

Further studies

  • Praetorian-DFT
  • RECOVER AF
  • UNCOVER AF
  • DISCOVER

Coronary Artery Disease

  • FAME 3
  • EBC Main

Heart Attack

  • RapidNSTEMI
  • PRE18FFIR

Valve Disease

  • PROGRESS-PVL
  • TRICINCH Coil
  • ON-X