Specimen requirements

Sample type: Serum (Serum)

Collection requirements: No special requirements

Cost

Price on application

Turnaround time

Please see Turnaround times

Analytical method

Immunoassay - Indirect / Competitive

Analysis undertaken at these site(s)

  • John Radcliffe Hospital
  • Churchill Hospital
  • Horton General Hospital

Reference intervals

09:00am cortisol <150 nmol/L - patient may have adrenal insufficiency (AI). Discuss with, or refer to Endocrinology.

09:00am cortisol 150 to 300 nmol/L - indeterminate, result may be normal. Interpret in the clinical context. Consider repeat test and Endocrinology consult.

09:00am cortisol > 300 nmol/L - adrenal insufficiency very unlikely.
NICE NG243

09:00am cortisol <50 nmol/L after overnight dexamethasone suppression excludes endogenous Cushing's syndrome.

A random (non-09:00am) cortisol or a value when the patient is taking steroid treatment is uninterpretable.