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Clinical Biochemistry

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O'Callaghan CA, Camidge C, Thomas R, Reschen ME, Maycock AJ, Lasserson DS, Fox RA, Thomas NPB, Shine B, James T. Evaluation of a simple low-cost intervention to empower people with chronic kidney disease to reduce their dietary salt intake: OxCKD1, a multi-center randomized controlled trial.
Kidney360. 2023 May 31. doi: 10.34067/KID.0000000000000160. Online ahead of print.

Shah RA, Mentzer AJ, James T, Cox S, Paddon K, Bowen J, Fullerton JN. A novel near-patient host-protein score predicts COVID-19 deterioration at presentation to secondary care. J Infect. 2023 May;86(5):534-536. doi: 10.1016/j.jinf.2023.01.017. Epub 2023 Jan 18.

Mirzazadeh M, Webster C, Weerasinghe G, Morris T, James T, Shine B. UK Reference Intervals for Parathyroid Hormone Using Abbott Methods. Br J Biomed Sci. 2023;80:11224.

Dockree S, Shine B, James T, Vatish M. Exclusion criteria for reference studies: Context is key. Ann Clin Biochem. 2023 Mar 19:45632231159785. doi: 10.1177/00045632231159785. Online ahead of print.

Dockree S, Shine B, James T, Vatish M. Pregnancy-specific reference intervals: should we exclude women based on body mass index? Ann Clin Biochem. 2023;60:146-147.

Rostom H, Noronha S, Jafar-Mohammadi B, May C, Borg A, Halliday J, Cudlip S, James T, Guha N, Shine B, Pal A. Post-pituitary surgery copeptin analysis as a 'rule-out' test for post-operative diabetes insipidus. Endocrine. 2023;79:358-364.

Tsakok MT, Watson RA, Saujani SJ, Kong M, Xie C, Peschl H, Wing L, MacLeod FK, Shine B, Talbot NP, Benamore RE, Eyre DW, Gleeson F. Reduction in Chest CT Severity and Improved Hospital Outcomes in SARS-CoV-2 Omicron Compared with Delta Variant Infection. Radiology. 2023;306:261-269.

Mogire RM, Muriuki JM, Morovat A, Mentzer AJ, Webb EL, Kimita W, Ndungu FM, Macharia AW, Cutland CL, Sirima SB, Diarra A, Tiono AB, Lule SA, Madhi SA, Prentice AM, Bejon P, Pettifor JM, Elliott AM, Adeyemo A, Williams TN, Atkinson SH. Vitamin D Deficiency and Its Association with Iron Deficiency in African Children. Nutrients. 2022;14:1372.


Taylor CA, Watson RA, Tong O, Ye W, Nassiri I, Gilchrist JJ, de Los Aires AV, Sharma PK, Koturan S, Cooper RA, Woodcock VK, Jungkurth E, Shine B, Coupe N, Payne MJ, Church DN, Naranbhai V, Groha S, Emery P, Mankia K, Freedman ML, Choueiri TK, Middleton MR, Gusev A, Fairfax BP. IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma. Nat Med. 2022;28:2592-2600.

Dockree S, O'Sullivan J, Shine B, James T, Vatish M. How should we interpret lactate in labour? A reference study. BJOG. 2022;129:2150-2156.

Chami J, Fleming S, Taylor CJ, Bankhead CR, James T, Shine B, McLellan J, Hobbs FR, Perera R. Point-of-care NT-proBNP monitoring for heart failure: observational feasibility study in primary care. BJGP Open. 2022 Sep 28;6(3):BJGPO.2022.0005.

Farmer AJ, Shine B, Armitage LC, Murphy N, James T, Guha N, Rea R. The potential for utilising in-hospital glucose measurements to detect individuals at high risk of previously undiagnosed diabetes: Retrospective cohort study. Diabet Med. 2022;39:e14918.

Rostom H, Meng X, Price H, Fry A, Elajnaf T, Humphrey R, Guha N, James T, Kennedy SH, Hannan FM. Protocol for an observational study investigating hormones triggering the onset of sustained lactation: the INSIGHT study. BMJ Open. 2022;12:e062478.

Withrow DR, Shine B, Oke J, Tamm A, James T, Morris E, Davies J, Harris S, East JE, Nicholson BD. Combining faecal immunochemical testing with blood test results for colorectal cancer risk stratification: a consecutive cohort of 16,604 patients presenting to primary care. BMC Med. 2022 Mar 15;20(1):

Higgins V, Ma L, Ragosnig BL, Melamed N, Hladunewich M, James T, Leite J, Rozmanc M, Barrett J, Zaltz A, Yip PM, Fu L. Analytical Performance and Quality Indicators of Fully Automated Immunoassays for sFlt-1 and PlGF. J Appl Lab Med. 2022;7:555-567

Mentzer AJ, James T, Yongya M, Cox S, Paddon K, Shine B, Bowen J, Novak A, Knight JC, Fullerton JN. Serum calprotectin is not an independent predictor of severe COVID-19 in ambulatory adult patients. J Infect. 2022;84:e27-e29.


Dockree S, Brook J, James T, Shine B, Vatish M. A pregnancy-specific reference interval for procalcitonin. Clin Chim Acta 2021;513:13-16.

Mogire RM, Morovat A, Muriuki JM, Mentzer AJ, Webb EL, Kimita W, Ndungu FM, Macharia AW, Cutland CL, Sirima SB, Diarra A, Tiono AB, Lule SA, Madhi SA, Sandhu MS, Prentice AM, Bejon P, Pettifor JM, Elliott AM, Adeyemo A, Williams TN, Atkinson SH. Prevalence and predictors of vitamin D deficiency in young African children. BMC Med. 2021 May 20;19(1):115.

Eyre DW, Lumley SF, O'Donnell D, et al. Stringent thresholds in SARS-CoV-2 IgG assays lead to under-detection of mild infections. BMC Infect Dis. 2021;21:187.

James T, Nicholson BD, Marr R, Paddon M, East JE, Justice S, Oke JL, Shine B. Faecal immunochemical testing (FIT): Sources of result variation based on three years of routine testing of symptomatic patients in English primary care. Br J Biomed Sci. 2021;78:211-217.

Dockree S, Brook J, Shine B, James T, Green L, Vatish M. Cardiac-specific troponins in uncomplicated pregnancy and pre-eclampsia: A systematic review. PLoS One. 2021;16:e0247946.

Dockree S, Brook J, James T, Shine B, Impey L, Vatish M. Pregnancy-specific reference intervals for C-reactive protein improve diagnostic accuracy for infection: a longitudinal study. Clin Chim Acta 2021 2021 Jun;517:81-85.

Dockree S, Brook J, Shine B, James T, Vatish M. Pregnancy-specific reference intervals for BNP and NT-pro BNP – changes in natriuretic peptides related to pregnancy. Journal of the Endocrine Society, 2021 May 15;5(7):bvab091.

Muriuki JM, Mentzer AJ, Mitchell R, et al. Malaria is a cause of iron deficiency in African children. Nat Med. 2021 Apr;27(4):653-658.

James TJ, Dow E. Foreword: Measurably Better Healthcare - Signs of a (R)Evolution in Progress Towards a New Academic Science? EJIFCC. 2021;32:4-6.

Broomfield J, Mason J, James T, Oddy S. Performance evaluation of the ADVIA Centaur PLGF and SFLT-1 assays. EuroMedLab Munich 2021. Clin Chem Lab Med 2021;59, Special Suppl, ppS94-S835.


Cerdeira AS, Kandzija N, Pargmae P, Tome M, Zhang W, Cooke WR, Agrawal S, James T, Redman C, Vatish M. In vivo evidence of significant placental growth factor release by normal pregnancy placentas. Sci Rep. 2020;10:132.

Parmanand B, Watson M, Boland KJ, Ramamurthy N, Wharton V, Morovat A, Lund EK, Collier J, Le Gall G, Kellingray L, Fairweather-Tait S, Cobbold JF, Narbad A, Ryan JD. Systemic iron reduction by venesection alters the gut microbiome in patients with haemochromatosis. JHEP Rep. 2020;2:100154.

Lawton M, Baig F, Toulson G, Morovat A, Evetts SG, Ben-Shlomo Y, Hu MT. Blood biomarkers with Parkinson's disease clusters and prognosis: The oxford discovery cohort. Mov Disord. 2020;35:279-287.

Smith I, Cerdeira AS, Thomas C, Vatish M, James TJ. Specimen Requirements for Preeclampsia Markers. The Journal of Applied Laboratory Medicine. 2020;5; 605-607.

Armstrong-Buisseret LK, Haslam S, James T, Bradshaw L, Heazell A. Verification of placental growth factor and soluble-fms-like tyrosine kinase 1 assay performance in late pregnancy and their diagnostic test accuracy in women with reduced fetal movement. Ann Clin Biochem 2020: 57: 223-233.

Eyre DW, Lumley SF, O'Donnell D, et al. Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study. Elife. 2020 Aug 21;9:e60675. doi: 10.7554/eLife.60675.

Sbardella E, Maunsell Z, May CJH, Tadman M, James T, Jafar-Mohammadi B, Isidori AM, Grossman AB, Shine B. Random 'spot' urinary metanephrines compared with 24-h-urinary and plasma results in phaeochromocytomas and paragangliomas. European Journal of Endocrinology 2020: 183: 129-139.

Nicholson BD, James T, Paddon M, Justice S, Oke JL, East JE, Shine B. Faecal immunochemical testing for adults with symptoms of colorectal cancer attending English primary care: a retrospective cohort study of 14 487 consecutive test requests. Aliment Pharmacol Ther. 2020;52:1031-1041.

Nicholson BD, East JE, Oke J, Roberts NW, James T, Shine B. Letter: extending FIT from DG30 to NG12 patients. Letter: faecal immunochemical testing for adults with symptoms of colorectal cancer - ready for prime time? Authors' reply: a unified approach to safety netting negative FITs is required. Aliment Pharmacol Ther. 2020;52:1420-1421.

Harman D, Duncan O, Slatter N et al. Patients with non-alcoholic fatty liver disease referred from primary care have a significant serum fibrosis marker and liver stiffness measurement discordance. 2020 Journal of Hepatology 2020:73:S407.

National SARS-CoV-2 Serology Assay Evaluation Group. Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison. Lancet Infect Dis. 2020;20:1390-1400.

Lumley SF, O'Donnell D, Stoesser NE, et al. Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers. N Engl J Med. 2020;384:533-540.


Shine B, James T, Adler A. In primary care, is measuring free-thyroxine plus thyroid-stimulating hormone to detect hypopituitarism cost-effective? A cost utility analysis using Markov chain models. BMJ Open. 2019;9:e029369. doi: 10.1136/bmjopen-2019-029369.

Cerdeira AS, O'Sullivan J, Ohuma EO, Harrington D, Szafranski P, Black R, Mackillop L, Impey L, Greenwood C, James T, Smith I, Papageorghiou AT, Knight M, Vatish M. Randomized Interventional Study on Prediction of Preeclampsia/Eclampsia in Women With Suspected Preeclampsia: INSPIRE. Hypertension. 2019;74:983-990.

Nicholson BD, Lee MM, Wijeratne D, James T, Shine B, Oke JL. Trends in Cancer Antigen 125 testing 2003-2014: A primary care population-based cohort study using laboratory data. Eur J Cancer Care (Engl). 2019 Jan;28(1):e12914. doi: 10.1111/ecc.12914.

Shah A, Wray K, James T, Shine B, Morovat R, Stanworth S, McKechnie S, Kirkbride R, Griffith DM, Walsh TS, Drakesmith H, Roy N. Serum hepcidin potentially identifies iron deficiency in survivors of critical illness at the time of hospital discharge. Br J Haematol. 2019 Jan;184(2):279-281. doi: 10.1111/bjh.15067.

Juszczak A, Pavić T, Vučković F, Bennett AJ, Shah N, Pape Medvidović E, Groves CJ, Šekerija M, Chandler K, Burrows C, Rojnić Putarek N, Vučić Lovrenčić M, Ćuća Knežević J, James TJ, Gloyn AL, Lauc G, McCarthy MI, Owen KR, Gornik O. Plasma Fucosylated Glycans and C-Reactive Protein as Biomarkers of HNF1A-MODY in Young Adult-Onset Nonautoimmune Diabetes. Diabetes Care. 2019 Jan;42(1):17-26.

Yang E, Chalisey A, Reschen ME, Shine B, Lasserson DS, O'Callaghan CA. Reduced kidney function at presentation in unselected acute emergency medical admissions: incidence, outcome and associated factors. Acute Med. 2019;18:158-164.

Ordóñez-Mena JM, Fanshawe TR, McCartney D, Shine B, Van den Bruel A, Lasserson D, Hayward G. C-reactive protein and neutrophil count laboratory test requests from primary care: what is the demand and would substitution by point-of-care technology be viable? J Clin Pathol. 2019 Jul;72(7):474-481.


Fairfax BP, Morgan RD, Protheroe A, Shine B, James T. Abiraterone acetate: a potential source of interference in testosterone assays. Clin Chem Lab Med. 2018 May 24;56(6):e13

Price CP, Smith I, Van den Bruel A. Improving the quality of point-of-care testing. Fam Pract. 2018 Jul 23;35(4):358-364.

Fanshawe TR, Ordóñez-Mena JM, Turner PJ, Bruel AVD, Shine B, Hayward GN. Frequencies and patterns of laboratory test requests from general practice: a service evaluation to inform point-of-care testing. J Clin Pathol. 2018 Dec;71(12):1065-1071.

Shine B, Barth JH. Big data in clinical biochemistry. Ann Clin Biochem. 2018 Sep 12:4563218800735. d

Hirst JA, Montes MDV, Taylor CJ, Ordóñez-Mena JM, Ogburn E, Sharma V, Shine B, James T, Hobbs FR. Impact of a single eGFR and eGFR-estimating equation on chronic kidney disease reclassification: a cohort study in primary care. Br J Gen Pract. 2018 Aug;68(673):e524-e530.

O'Sullivan JW, Heneghan C, Perera R, Oke J, Aronson JK, Shine B, Goldacre B. Variation in diagnostic test requests and outcomes: a preliminary metric for Sci Rep. 2018 Mar 19;8(1):4752.

Emms H, Farah G, Shine B, Boot C, Toole B, McFadden M, Lam L, Ou ZQ, Woollard G, Madhavaram H, Kyle C, Grossman AB. Falsely elevated plasma metanephrine in patients taking midodrine. Ann Clin Biochem. 2018 Jul;55(4):509-515.

Böhning D, Böhning W, Guha N, Cowan DA, Bartlett C, Sönksen PH, Holt RIG. A correction to the age-adjustment of the GH-2000 score used in the detection of growth hormone misuse. BMC Res Notes. 2018 Sep 5;11(1):650.

Sönksen PH, Holt RIG, Böhning W, Guha N, Cowan DA, Bartlett C, Böhning D. Why do endocrine profiles in elite athletes differ between sports? Clin Diabetes Endocrinol. 2018 Feb 7;4:3.

Sőnksen PH, Bavington LD, Boehning T, Cowan D, Guha N, Holt R, Karkazis K, Ferguson-Smith MA, Mircetic J, Bőhning D. Hyperandrogenism controversy in elite women's sport: an examination and critique of recent evidence. Br J Sports Med. 2018 Dec;52(23):1481-1482.

Lorenzini M, Guha N, Davison JE, Pitcher A, Pandya B, Kemp H, Lachmann R, Elliott PM, Murphy E. Isolated aortic root dilation in homocystinuria. J Inherit Metab Dis. 2018 Jan;41(1):109-115.

Last reviewed:03 August 2023