ZnT8 Antibody testing is performed by a referral laboratory. This assay is only available to members of Oxford University Hospitals NHS Foundation Trust.
Autoantibodies to pancreatic beta cell antigens are important serological markers of type 1 diabetes mellitus (T1D). The antigens recognised by these antibodies include insulin, glutamic acid decarboxylase (GAD65), the islet cell antibodies, islet tyrosine phosphatase 2 (IA2) antibodies.and zinc transporter 8 (ZnT8). ZnT8 Ab are directed principally to the C terminal domain of ZnT8.
Zinc transporter 8 (ZnT8) is vital for the biosynthesis and secretion of insulin and ZnT8 autoantibodies (ZnT8A) are among the most recently discovered and least-characterised islet autoantibodies.
Specimen requirements
Serum 1ml; plasma is NOT acceptable
Cost
Price on application
Laboratory turnaround time
7 days
Laboratory method
ELISA
Reference range/units
Positive >=15 RU/ml
Negative <15 RU/ml
Associated tests
N/A
Shipping and storage
Internal hospital transport/courier.
Ensure delivery Monday to Friday 07:00 - 17:30.
Further information and contact details
For further information, email immunologylab.enquiries@ouh.nhs.uk
