Tryptase

Also known as: Mast Cell Tryptase; Serum Tryptase

Serum Tryptase is a marker of mast cell degranulation. Tryptase measurement is of value in the assessment of selected cases of anaphylactic/anaphylactoid reactions and in the investigation of suspected mastocytosis. An elevated tryptase does not distinguish between anaphylaxis and anaphylactoid reactions. Also see investigation of anaesthetic reactions.

In the investigation of anaphylaxis 3 blood samples should be taken recorded with the time and date of collection:

1. At the time of the reaction (within 1 hour or as soon as possible)
2. No later than 4 hours post onset of symptoms
3. A future random sample to determine baseline level

Specimen requirements

Serum 1ml. Serum preferred but can test Plasma

Cost

Price on application

Laboratory turnaround time

3 days

Laboratory method

Immunocap automated Enzyme Immunoassay

Reference range/units

0-16 micrograms per litre

Associated tests

• Total IgE
• Specific IgE

Sample stability

2 months at 2-8ºC

Shipping and storage

UK and Ireland

Ambient temperature and first class post. Hays DX users please enquire via email below.

International

Ambient temperature if courier will deliver within 72 hours otherwise consider refrigerated transport. Freezing is not a requirement.

Ensure delivery Monday to Friday 09:00 - 17:30.

Further information and contact details

For further information, email immunology.office@nhs.net