Also known as: Thrombospondin Type-1 Domain Containing 7A Antibodies.
Membranous glomerulonephritis (MG) is an autoimmune disease which typically presents with nephrotic syndrome or proteinuria. One-third of patients progress to end-stage renal disease. MG is more common in males than females (2:1) and has a peak incidence between 40 and 50 years of age.
It is associated with autoantibodies against podocyte antigens present in the Bowman's capsule of the kidneys. The deposition of these antibodies leads to activation of complement at the podocyte surface, cell injury and urinary protein loss. MG can be classified as either primary (idiopathic), which occurs in 75% of cases, or secondary. Secondary membranous is associated with malignancy, autoimmunity, infection and drugs
This assay is performed at a referral laboratory (external users requiring serum THSD7A antibody levels are advised to contact the referral laboratory directly):
Department of Immunology
PO Box 894
Sheffield S5 7YT
Specimen requirements
Serum 1ml; plasma is NOT acceptable
Cost
Price on request
Laboratory turnaround time
28 days
Email immunologylab.enquiries@ouh.nhs.uk for current turnaround time
Laboratory method
Indirect immunofluorescence (IIF) using a transfected cell line
Reference range/units
Negative = Normal
Associated tests
N/A
Shipping and storage
Internal hospital transport/courier.
Ensure delivery Monday to Friday 07:00 - 17:30.
Further information and contact details
For further information, email immunologylab.enquiries@ouh.nhs.uk
