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Immunology Laboratory

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Smooth Muscle Antibodies

Also known as: SMA; F-Actin

Smooth muscle auto-antibodies are associated with autoimmune chronic active hepatitis (CAH). The major auto-antigen being F-Actin. IgG smooth muscle antibodies to F-Actin are present at high titre in about 70% of autoimmune active chronic hepatitis (non hepatitis B/C) and in approximately 25 - 50% of patients with primary biliary cirrhosis. These antibodies often occur as a 'false positive' in patients with viral infections.

Specimen requirements

Serum 1ml


Price on application

Laboratory turnaround time

5 days

Laboratory method

Indirect Immunofluorescence

Reference range/units

Positive or Negative with a titre

Associated tests

Part of Autoantibody screen

Sample stability

2 months at 2-8ÂșC

Shipping and storage

UK and Ireland

Ambient temperature and first class post. Hays DX users please enquire via email below.


Ambient temperature if courier will deliver within 72 hours otherwise consider refrigerated transport. Freezing is not a requirement.

Ensure delivery Monday to Friday 09:00 - 17:30.

Further information and contact details

For further information, email

Last reviewed:09 October 2023