Haemolytic Complement Activity - Classical and Alternative Pathways
Also known as: CH50; AP50; CH100; AP100
Test of integrity of classical and alternate lytic pathways of complement. Such conditions are rare and present either with a predisposition to recurrent bacterial infections, especially meningococcal (C5-9, properdin) and pneumococcal infection (C1-4), or with increased susceptibility to immune complex diseases such as SLE (C1-4).
NB If you suspect this condition, we suggest that you discuss this with an Immunologist prior to requesting this assay.
Specimen requirements
Serum - 1ml
Cost
Price on application
Laboratory turnaround time
31 days
Laboratory method
Haemolytic
Reference range/units
Reported as Normal or a percentage of normal.
Normal is equal or >80% of the control.
Associated tests
Not applicable
Shipping and storage
Sample needs to reach the Laboratory within 8 hours of venepuncture.
Patients with any form of meningococcal disease, particularly if recurrent, should be screened in convalescence with a CH100.
Further information and contact details
For further information, email immunology.office@nhs.net