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Immunology Laboratory

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Gastric Parietal Cell Antibody

Also known as: GPC

Gastric parietal cell antibodies (GPC) are directed against a parietal cell enzyme, the H+K+ATPase. The auto-antibody is found at high frequency in association with autoimmune gastritis and a proportion of these patients will progress to develop pernicious anaemia. Gastric parietal cell antibodies are present in over 90% of patients with pernicious anaemia (Highly sensitive, but not specific).

GPC antibodies should be looked for in:

  • Vitamin B12 deficiency
  • Macrocytic anaemia
  • Subacute combined degeneration of the cord
  • Individuals with other autoimmune disease i.e. thyroid disease

Specimen requirements

Serum 1ml


Price on application

Laboratory turnaround time

10-14 days

Laboratory method

Indirect Immunoflourescence

Reference range/units

Positive or Negative

Associated tests

Intrinsic Factor Antibodies

Sample stability

2 months at 2-8ÂșC

Shipping and storage

UK and Ireland

Ambient temperature and first class post. Hays DX users please enquire via email below.


Ambient temperature if courier will deliver within 72 hours otherwise consider refrigerated transport. Freezing is not a requirement.

Ensure delivery Monday to Friday 09:00 - 17:30.

Further information and contact details

For further information, email

Last reviewed:06 October 2023