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Immunology Laboratory

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Centromere Antibodies

Also known as: CENP; CENPB; ANA

Centromere antibodies occur in several auto-immune conditions; frequently in Limited Systemic Scleroderma (formerly called CREST Syndrome), and occasionally are found in the diffuse form of Scleroderma. They are rare in other Rheumatic conditions and in healthy persons. They are found in 55-70% of patients with Limited Systemic Scleroderma, and in 15% of those with the diffuse form. The specificity of this test is >98%.

Please Request ANA for this test.

Specimen requirements

Serum 1ml


Price on application

Laboratory turnaround time

1-2 days

Laboratory method

Immunofluorescence and/or EliA automated Enzyme Immunoassay

Reference range/units

Reported as Positive or Negative with a comment

Associated tests

Not applicable

Shipping and storage

UK and Ireland

Ambient temperature and first class post. Hays DX users please enquire via email below.


Ambient temperature if courier will deliver within 72 hours otherwise consider refrigerated transport. Freezing is not a requirement.

Ensure delivery Monday to Friday 09:00 - 17:30.

Further information and contact details

For further information, email

Last reviewed:06 October 2023