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Immunology Laboratory

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Cardiac Muscle Antibodies

Please note: Cardiac Muscle Antibody testing is performed by a referral laboratory. This assay is only available to members of Oxford University Hospitals NHS Foundation Trust.

Cardiac muscle antibodies are described in patients with Dressler’s syndrome after myocardial infarction, cardiomyopathy, myocarditis and in patients who have undergone cardiac surgery or have had rheumatic fever. They can be directed towards a number of antigens such as adenine nucleotide translocator protein, cardiac myosin and tropomysin. The presence of antibodies can occur without the Dressler syndrome. (Source:

This assay is performed at a referral laboratory (external users requiring serum Cardiac Muscle Antibodies are advised to contact the referral laboratory directly):

Department of Immunology
PO Box 894
S5 7YT

Specimen requirements

Serum 2ml; plasma is NOT acceptable.



Laboratory turnaround time

28 days

Laboratory method

Indirect immunofluorescence (IIF).

Reference range/units

Results are reported as either NEGATIVE or POSITIVE, with pattern as follows:-

  1. Striational
    A striational pattern is seen in both cardiac and skeletal muscle but sometimes seen more prominently in skeletal muscle than cardiac muscle. This may be associated with Myasthenia Gravis and thymoma (See skeletal muscle).
  2. Myocardial
    If myocardial antibodies are positive, the pattern is reported as anti-sarcolemmal or anti-fibrillary.

Associated tests

Skeletal Muscle Antibodies

Shipping and storage

Internal hospital transport/courier.

Ensure delivery Monday to Friday 07:00 - 17:30.

Further information and contact details

For further information, email