ZnT8 Antibodies

ZnT8 Antibody testing is performed by a referral laboratory. This assay is only available to members of Oxford University Hospitals NHS Foundation Trust.

Autoantibodies to pancreatic beta cell antigens are important serological markers of type 1 diabetes mellitus (T1D). The antigens recognised by these antibodies include insulin, glutamic acid decarboxylase (GAD65), the islet cell antibodies, islet tyrosine phosphatase 2 (IA2) antibodies.and zinc transporter 8 (ZnT8). ZnT8 Ab are directed principally to the C terminal domain of ZnT8.

Zinc transporter 8 (ZnT8) is vital for the biosynthesis and secretion of insulin and ZnT8 autoantibodies (ZnT8A) are among the most recently discovered and least-characterised islet autoantibodies.

This assay is performed at a referral laboratory (external users requiring serum ZnT8 antibody levels are advised to contact the referral laboratory directly):

Department of Immunology
PO Box 894
Sheffield S5 7YT

Specimen requirements

Serum 1ml; plasma is NOT acceptable

Cost

Price on application

Laboratory turnaround time

20 days

Laboratory method

ELISA

Reference range/units

Positive >15 U/ml
Negative =<15 U/ml

Associated tests

N/A

Shipping and storage

Internal hospital transport/courier.
Ensure delivery Monday to Friday 07:00 - 17:30.

Further information and contact details

For further information, email immunology.office@nhs.net