THSD7A Antibodies

THSD7A Antibody testing is performed by a referral laboratory. This assay is only available to members of Oxford University Hospitals NHS Foundation Trust.

Membranous glomerulonephritis (MG) is an autoimmune disease which typically presents with nephrotic syndrome or proteinuria. One-third of patients progress to end-stage renal disease. MG is more common in males than females (2:1) and has a peak incidence between 40 and 50 years of age.

It is associated with autoantibodies against podocyte antigens present in the Bowman's capsule of the kidneys. The deposition of these antibodies leads to activation of complement at the podocyte surface, cell injury and urinary protein loss. MG can be classified as either primary (idiopathic), which occurs in 75% of cases, or secondary. Secondary membranous is associated with malignancy, autoimmunity, infection and drugs

This assay is performed at a referral laboratory (external users requiring serum THSD7A antibody levels are advised to contact the referral laboratory directly):

Department of Immunology
PO Box 894
Sheffield S5 7YT

Specimen requirements

Serum 1ml; plasma is NOT acceptable

Cost

Price on application

Laboratory turnaround time

28 days

Laboratory method

Indirect immunofluorescence (IIF) using a transfected cell line

Reference range/units

Negative = Normal

Associated tests

N/A

Shipping and storage

Internal hospital transport/courier.
Ensure delivery Monday to Friday 07:00 - 17:30.

Further information and contact details

For further information, email immunology.office@nhs.net