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Oxford University Hospitals NHS Foundation Trust

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Investigating Pain Mechanisms in Endometriosis

Trial categories: Brain; Women's health

Sponsoring organisation: University of Oxford

Investigating pain mechanisms in endometriosis: a multimodal study to identify mechanisms and markers of central and inflammatory pain in women with endometriosis

We are recruiting women with endometriosis-associated pain for whom surgery is planned at the John Radcliffe Hospital.

Pain is a complex and emotional experience affected by many different factors. We know that pain can be generated in a number of ways, by nerve endings at the site of an injury (nociceptive pain); chemicals released by cells at the injured site (inflammatory pain) or damaged nerves both in and outside the brain (neuropathic or central pain). It is plausible that all three types of mechanisms contribute to pain in endometriosis, which may explain the inconsistent and varied clinical features and responses to therapy.

In this study, we hope to gain a better understanding of the various mechanisms generating pain in endometriosis and the data we collect will cover the above aspects. By doing so, we hope to identify markers for different types of pain and treatment targets for the specific type of pain. We hope this will enable better clinical trials in the future and ultimately help the development of personalized treatment regimes.

Unfortunately, we must ask you to not participate if you cannot have an MRI (Magnetic Resonance Imaging) scan e.g. you have metallic implants, stents, clips etc.; if you have been taking medication that has an effect on the brain in the last three months e.g. treatment of epilepsy, depression including taking gabapentin or pregabalin, duloxetine medication or if you are pregnant.

Due to the types of questionnaires we will use, you will not be able to participate if you are not able to speak and understand written English.

If you are scheduled to have surgery at the John Radcliffe Hospital to treat long standing pelvic pain believed to be due to endometriosis, please contact:

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