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Oxford University Hospitals NHS Foundation Trust
Oxford Kidney Unit

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Research studies currently recruiting

This information is about research projects and clinical trials that are recruiting in the Oxford Renal and Transplant Unit. Updated December 2016.

RADAR

The National Registry of Rare Kidney Diseases (RaDaR) is an initiative by UK kidney specialists (the Renal Association). It is designed to pull together information from patients who have certain rare kidney diseases. This will give a much better understanding of how these illnesses affect people. It will also speed up research.

This work is done in partnership with patients. Where the research leads to practical benefits, such as better diagnosis, treatments or general advice this will be publicised on this website.

Dr Ed Sharples is the Consultant in charge of this project in Oxford.

We will be directly approaching suitable patients, but if you are interested please feel free to contact Karen Parsons.

PDOPPS

The Peritoneal Dialysis Outcomes and Practice Patterns Study

This study is called the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS). It is hoped this study will lead to better treatment and better lives for patients on peritoneal dialysis (PD).

We will collect information on about 5,000 PD patients in five countries over three years. It will link in to the UK Renal Registry for information already stored such as demographics and test results and will involve optional annual Quality of Life questionnaires. It is suitable for patients on PD or about to start PD.

Participants may be chosen randomly to enter this study.

Patients recruited already on PD can also enter the sub-study detailed below.

Biological Determinants of Peritoneal Dialysis Outcomes Sub-Study - BioPD

In Peritoneal Dialysis (PD), water and toxins move from the blood into the dialysis fluid across the lining of the abdomen, which is called the peritoneal membrane. This sub-study wants to find out if differences in how the peritoneal membrane works depend upon the genes that people inherit, in other words the DNA with which people are born.

All blood and dialysis fluid samples will be sent to the University of Washington, Seattle, USA for testing and storage. The study team at the University of Washington will extract DNA from the blood. They will look for specific portions of the DNA and 'read' or sequence larger portions of DNA. They may compare the entire sequence of the DNA, which is called the genome, with genomes from different people using a technique called Genome-Wide Association Study (GWAS).

Dr Ed Sharples is the Consultant in charge of this project in Oxford and being performed by the PD Team under the charge of Jayne Woodhouse.

OX HARP-1

OX HARP (Heart and Renal Protection)-I

This is a small feasibility study to see whether patients with CKD are happy to use some telemonitoring equipment to monitor their blood pressure at home. The equipment measures blood pressure with a normal machine which then sends the information to a tablet device which in turn sends the information to a central computer in the hospital.

This method could be used in trials comparing different blood pressure targets (and avoid lots of visits to a study clinic) or in routine practice (to get a better idea of what an individual's usual blood pressure is).

Dr Richard Haynes is the Consultant in charge of this project in Oxford. If you're interested in participating, please contact the renal research team.

OWDDS

Oxford Wearable Dialysis Devices

"People on dialysis are more likely to develop an abnormal heart than the general population and we want to try and prevent and treat heart disease in our dialysis patients. We are therefore planning new trials and want to include new devices to identify abnormal heart rhythms and measure physical activity levels.

"We therefore want to recruit 100 dialysis people to wear heart monitors and wrist-worn physical activity devices for two weeks to test the acceptability of such devices and test if they provide useful information about the health of dialysis patients. This will help us design the proposed new trials."

Dr Will Herrington is the Consultant in charge of this project in Oxford. If you're interested in participating, please contact the renal research team.