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Oxford University Hospitals NHS Foundation Trust
Immunology

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HMGCR Autoantibodies

Also known as: HMG; Statin associated myopathy; necrotising myopathy

The clinical management of inflammatory myopathies can be guided according to the demonstation of Myositis specific autoantibodies (MSA).

Recently, a novel MSA to the enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) was shown to be strongly associated with immune mediated necrotising myopathy (Arthritis Rheum. 2010 Sep;62(9):2757-66. doi: 10.1002/art.27572). These patients present with progressive, irritable Myopathy of the proximal muscles and typically have a Creatinine Kinase level greater than 10x the upper limit of normal.

Patients present in two main catagories:

  1. Those under the age of 45 who have typically not been exposed to statins tend to have a more severe disease course.
  2. Those over the age of 45 typically develop a myopathy within 6 months of statin exposure which fails to resolve upon statin cessation and requires immunosuppression.

Specimen requirements

0.5ml of separated serum

Cost

£15

Laboratory turnaround time

14 working days

Laboratory method

ELISA

Reference range/units

Negative/Positive

Associated tests

Myositis Western blot

Shipping and storage

UK and Ireland

Ambient temperature and first class post. Hays DX users please enquire via email below.

International

Ambient temperature if courier will deliver within 72 hours otherwise consider refrigerated transport. Freezing is not a requirement.

Ensure delivery Monday to Friday 07:00 - 17:30.

Further information and contact details

For further information, email andrew.woods2@nhs.net