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Oxford University Hospitals NHS Foundation Trust

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Cytogenetics specimen requirements

General Specimen requirements

All samples MUST be accompanied by a referral form

Blood samples – Chromosomes/Karyotype

LITHIUM HEPARIN tube

  • Adults 2-5mls, Children 1-2mls, Fetal/Neonates 0.5-1ml
  • Blood samples should arrive within 24 hours of collection
  • Fetal/Neotatal samples should arrive the same day

Blood samples – Arrays

EDTA tube

  • Adults 2-5mls, Children 1-2mls, Fetal/Neonates 0.5-1ml
  • Blood samples should arrive within 24 hours of collection
  • Fetal/Neotatal samples should arrive the same day

Amniotic Fluid samples

Sterile UNIVERSAL

  • 10-20mls
  • Should arrive within 24 hours, room temperature

Chorionic Villis (CVS) samples

Transport Medium (supplied by the lab)

  •  10-20mls, room temperature

Fetal Tissue samples/POC

Cord Blood – 0.5-1ml Paediatric LITHIUM HEPARIN
Placenta – 1 cubic cm, Transport medium
Skin Biopsy – full depth, Transport medium
Spleen/lung/other tissue – 1 cubic cm, Transport medium

  • Should arrive within 24 hours
  • Do NOT fix these tissues.

Skin biopsy sample (adult/child)

Transport Medium (supplied by the lab)

  • Skin punch 2 cubic cm
  • Should arrive within 24 hours

Bone Marrow

Transport Medium (supplied by the lab), if not available, LITHIUM HEPARIN tube

  • 1ml
  • Should arrive within 24 hours - same day preferred

Lymph Node

Transport Medium (supplied by the lab)

  • 1 cubic cm
  • Same day essential

Tumour

Transport Medium (supplied by the lab)

  • 1 cubic cm
  • Same day essential

Fixed tissue slides

  • FFPE tissue sections mounted on slides need to be in a slide box and packaged with plenty of padding.
  • Suitable types of transport medium are supplied by the laboratory, on request
  • Delays in transit can result in sample failure or sub-optimal results
  • If necessary, specimens should be stored at 4 degrees (refrigerator temp) overnight or at the weekend for delivery as soon as possible the next day.

Additional samples types may be accepted for analysis. Clinicians are advised to contact the laboratory to discuss specific specimen requirements prior to arranging specimen collection

Last updated: 18 October 2017 by Claire Scott.

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