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Oxford University Hospitals NHS Foundation Trust

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IgD Level

Please Note: Serum IgD Level testing is performed by a referral laboratory. This assay is only available to members of Oxford University Hospitals NHS Foundation Trust.

High Serum IgD levels are associated with Autoinflammatory disorders: Test Hyper IgD syndrome (HIDS) is a rare disorder with features of recurrent bouts of fever, lymphadenitis and occasionally arthritis. The majority, over 70%, of patients have an IgD level of >100 u/mL and therefore over 20% of patients have an IgD level within the reference range. The underlying genetic defect is a mutation of the mevalonate kinase (MVK) gene leading to mevalonate kinase deficiency (MKD). High IgD levels can occur in other conditions with a normal MVK genotype. (Source:

This assay is performed at a referral laboratory (external users requiring serum IgD levels are advised to contact the referral laboratory directly):

The Department of Immunology
PO Box 894
S5 7YT

Specimen requirements

Serum 1ml; plasma is NOT acceptable



Laboratory turnaround time

28 days

Laboratory method


Reference range/units

2-100 kU/L

Associated tests


Shipping and storage

UK and Ireland

Ambient temperature and first class post. Hays DX users please enquire via email below.


Ambient temperature if courier will deliver within 72 hours otherwise consider refrigerated transport. Freezing is not a requirement.

Ensure delivery Monday to Friday 07:00 - 17:30.

Further information and contact details

For further information, email